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Reduced expression of tyrosine hydroxylase and TPH, biochemical markers of neuronal integrity, was observed after mephedrone administration, along with downregulation of dopamine D2 receptors in the striatum, indicating the presence of damaged nerve endings 48,49

Fan Z, Pan YT, Zhang ZY, Yang H, Yu SY, Zheng Y, Ma JH, Wang XM (2020) Systemic activation of NLRP3 inflammasome and plasma -synuclein levels are correlated with motor severity and progression in Parkinsons disease

Materials and methods Animals Locally bred male Albino-Wistar rats (n = 12) utilised in the study, were purchased from Dow University of Health Sciences, OJHA campus, Karachi, Pakistan

Currently, only few studies have investigated the urine inflammatory protein profiles between IC/BPS and OAB 12,13