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This reaction is temperature-dependent and essentially irreversible once it occurs

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Abstract: Njlsson R

This discovery suggests that in the future, immune-suppressive agents may be used together with ADI-PEG20 for drug resistance due to ADI-PEG20 neutralizing antibodies upon prolonged treatment

Springer International Publishing, Cham, pp 155172 Moustakli E, Zikopoulos A, Sakaloglou P, Bouba I, Sofikitis N, Georgiou I (2023) Functional association between telomeres, oxidation and mitochondria