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It regulates neuronal firing patterns and frequencies, enhancing information encoding efficiency in the motor cortex while optimizing the excitation-inhibition balance, thereby improving the overall functional state of neural networks (Marino et al., 2023)

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Toxic levels of methotrexate can be rapidly and effectively decreased by intravenous administration of glucarpidase, which has been shown to induce a 99% or greater sustained reduction of serum methotrexate levels (Widemann 2014)