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Description

Parkinsons disease (PD) is primarily characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and subsequent depletion of dopamine in the nigrostriatal pathway

However, in some cases drugs are only predicted to be effective if multiple of their targets are knocked out in the drug deletion pipeline

Crystal structure of CD38 in complex with daratumumab, a first-in-class anti-CD38 antibody drug for treating multiple myeloma

Caceres-Delpiano J, Wang LP, Essex JW (2021) The automated optimisation of a coarse-grained force field using free energy data

Methods: We searched PubMed and Embase for studies according to predefined selection criteria and we assessed their quality according to a predefined risk of bias scale