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Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

5.2 Safety and toxicological concerns Even as nanoencapsulation solves bioavailability issues, it introduces new questions about the safety of ingesting nanoparticles over time

doi: 10.1160/TH07-01-0039 15 JeonC

In addition, ADCs can also exert an extracellular action on neighbouring cells via the release of the payload after intracellular cleavage of the linker (bystander effect), which is mediated by the proteases localised in lysosomes

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