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Different tissues co-expressed the protein with mitochondria, and plasma also contained the protein, but its level decreased with age

In vivo, zinc deficiency does not independently induce ER stress, yet under pharmacologically induced ER stress conditions, zinc-deficient mice exhibit heightened activation of the pro-apoptotic p-eIF2ATF4CHOP axis, accompanied by apoptosis, steatosis and liver injury

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2 Materials and methods 2.1 Animal management, diets, and experimental design A total of 128 growing-finishing pigs (Duroc Landrace Yorkshire) with an initial average body weight of 33.88 0.62 kg were assigned to four treatments in a randomized complete block design based on body weight