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The development of biomarkers and imaging tools capable of confirming synaptic target engagement in vivo will be critical for successful clinical translation (Jackson et al., 2019)

A process for the preparation of reduced glutathione, which comprises dissolving or suspending in water the reduced glutathione in amorphous spherical form of claims 1 -6 at concentrations higher than 700 g/l, preferably from 700 to 1000 g/l, and more preferably from 800 to 1000 g/l, and subsequent isolation thereof in crystalline form

Kern et al., 2014)

If response is adequate, treatment is continued for one week as most side effects of NSAIDs appear in the first week

Ohkawa K, Tsukada Y, Dohzono H, Koike K, Terashima Y