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New antifibrotic treatments indicated for idiopathic pulmonary fibrosis offer hopes and raises questions

Furthermore, PKA phosphorylates and regulates the activity and expression of the cAMP-response element modulator (CREM) protein family, a group of transcription factors playing an important role in various cellular functions (82)

On the one hand, it reduces the avidity of importin for phenylalanine-glycine-rich nucleoporins (FG-nups), thereby facilitating the passage of import complexes through the permeability barrier