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In fact, ROS facilitates TLR4 trafficking to the plasma membrane, thereby promoting the TLR4 activity (83, 84)

For example, non-steroidal anti-inflammatory drugs often prescribed for pain management have been associated with gastrointestinal disturbances, raising concerns about their long-term use in ME/CFS patients who already report high levels of gut-related issues [185, 186]

Additionally, the utilization of UDE containing 1000M -EC resulted in a negative impact on cell viability, whereas treatment with 1000M -EC alone did not exhibit any toxic eects