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ET-1 antagonism: bosentan Bosentan, an ET-1 receptor antagonist, has been applied in the treatment of HAPH

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Interestingly, two thirds of such replacements are in highly and moderately conserved (50% to 99%) amino acids, and relatively few are in fully conserved amino acids (where they might be lethal) or in poorly conserved amino acids, where presumably they simply would not cause G6PD deficiency