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Contemporary trial data in high risk patient groups do not show convincing evidence that intensive lipid lowering causes major neurocognitive harm, dementia, or a clear excess of haemorrhagic stroke in selected patients, even at very low achieved LDL-C levels [9], [10], [11], [12], [13], [14], [15], [16]

J Mol Neurosci 48:6676 Camire RB, Beaulac HJ, Willis CL (2015) Transitory loss of glia and the subsequent modulation in inflammatory cytokines/chemokines regulate paracellular claudin-5 expression in endothelial cells

Reduced lipid peroxidation markers in keratinocytes exposed to hydrogen peroxide, suggesting direct cytoprotection against oxidative insult

Intestinal immune cells and their secreted inflammatory factors can migrate to the brain through peripheral circulation after the IEB is damaged during stroke (Jiang et al., 2023)