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The copper ion is essential for biological activity the apo-peptide (GHK without copper) shows markedly reduced activity in most assay systems

This has made it an important research tool for appetite regulation, food intake and energy homeostasis

Conducting such trials rigorously, with controls, and considering dose size and frequency are necessary

Additionally, predictions via the oncoPredict algorithm revealed significant associations between the gene risk score and drug sensitivity in lung adenocarcinoma patients, providing a robust molecular basis for both immunotherapy and drug sensitivity prediction and offering new avenues for personalized treatment strategies