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Carbon-centered lipid radicals (R ) rapidly react in oxygenated tissues with the molecular oxygen-forming lipid peroxyl radicals (ROO) according to the reaction (Valko et al

However, grape juices ability to increase the production of NO in endothelial cells does not appear to rely solely on its major antioxidant named resveratrol

The oxidative stress-induced weakening of the fibrous cap covering the plaque, due to the degradation of extracellular matrix components by matrix metalloproteinases (MMPs), is a key factor in plaque instability [75]

In comparison to monocyte-derived macrophages from healthy volunteers, macrophages from patients with active CD were more susceptible to ferroptosis induced by in vitro exposure to H 2 O 2

They also display microgliosis, astrocytosis and synapse loss, in addition to cognitive impairment at 6 months of age