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Vitamin B12 is a cofactor in synthesizing methionine, which is essential for protein formation.[ref] If you are deficient in B12 or folate for a long time, you can develop megaloblastic anemia

Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice

Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients

A B12 deficiency can lead to signs such as fatigue and lowered appetite, and as many as 16% of U.S

This can be a sign of overhydration (drinking too much water)