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The underlying mechanism of copper-induced cell death was unclear until the article Copper induces cell death by targeting lipoylated TCA cycle proteins was published by Tsvetkov et al

In healthy young adults (yellow curves), robust high-amplitude circadian rhythms are evident in diverse physiological variables (activity levels, core body temperature, SCN firing rate, hormonal secretion such as melatonin and cortisol, glucose metabolism, etc.) across the 24-h day

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function