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In an induced fit scenario, the ligands bind to the single open protein structure and the interaction between a protein and a rigid binding partner induces a conformational change in the protein

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To provide further mechanistic insight into the role of IGF-1/IGF-1R in NK cell development, we investigated the levels of IRS-1 in human CD34 + cells cultured with either IL-15 or the combination of IL-15 and IGF-1 at 14 or 21 days and compared it with the levels of IRS-1 in 293A cells, which usually expressed normal levels of IRS-1

[PubMed: 10569383] (Retrospective analysis of patients admitted to four hospitals over 4 years