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In addition, RAGE was expressed in filopodial membranes of myofibroblasts suggesting a role of RAGE in spreading and migration of activated HSC in fibrogenesis [123]

Moreover, studies using paired tumor organoids derived from before and after NAC have suggested that chemotherapy can induce adaptive transcriptional programs related to epithelialmesenchymal transition (EMT) and hypoxia, supporting the concept of acquired resistance under therapeutic pressure [11]