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The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

doi:10.1111/j.1440-0960.2011.00866.x

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Instead, the observed stimulation likely results from active degradation and conformational shifts to substrate-processing states, with increased ATP hydrolysis and an open gate of the 20S core particle