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Most patients describe the injections as a small pinch

Clinical studies have shown significant improvement in withdrawal symptoms in most patients treated with DSIP, with minimal side effects

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Immune system regulation: Some beneficial strains in the gut microbiota, such as lactobacilli and bifidobacteria ( Metabolites and signaling pathway regulation: Metabolites produced by gut microbiota can reach the brain through blood circulation, affecting the metabolism and signal transduction of GBM cells ( The neuroendocrine communication regulation of the gut brain axis: gut microbiota can affect neurotransmitters ( Dietary and therapeutic response: Dietary components directly affect the composition and activity of gut microbiota, thereby affecting the hosts nutritional metabolism ( Potential role of microbiome therapy: Fecal microbial transplantation (FMT) from healthy donors to GBM patients aims to restore gut microbiota balance, enhance anti-tumor immunity, and improve the TME ( In depth study of these interaction mechanisms is expected to provide scientific basis for the development of new GBM treatment strategies, especially by combining existing treatment methods with gut microbiota regulation technologies

Thus, our data suggest downmodulation of CCR2 as a possible compensatory mechanism in response to sustained overproduction of CCL2 or continuous trafficking of CCR2 + cell into tissues (82)