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TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

Abnormality in globin chain synthesis (e.g., thalassemia) 2

In breast cancer, oxidized Hsp90 (with reduced SSG) is associated with a poor treatment response, while the SSG of GSTP at Cys411/420 counteracts bortezomib resistance in multiple myeloma by impairing ATPase binding and protein folding (97)