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When a person loses weight and the levels of circulating appetite-related hormones change, the hypothalamus adjusts parameters such as energy homeostasis, nutrient metabolism, and subjective appetite in response

Bioinformatics analysis (UbiBrowser) and literature mining were used to predict potential FBXO22-regulated targets, including KDM4A, p53, CD147, PTEN, BAG3, LKB1, KLF4, BACH1, Snail, and HDM2