glutathione levels in breast cancer cells

glutathione levels in breast cancer cells (GSH) Human Cell Lines Exposed for 24 h to Each Glutathione metabolism in cancer progression

Name: glutathione levels in breast cancer cells (GSH) Human Cell Lines Exposed for 24 h to Each Glutathione metabolism in cancer progression
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Glutathione metabolism in cancer progression and treatment resistance Journal of Cell Biology Rockefeller University Press Unveiling the Role of Glutathione S transferase Protein in Breast Cancer Drug Resistance: Insights into the Signaling Pathways and Therapeutic Implications ACS Pharmacology & Translational Science Glutathione and Xanthine Metabolic Changes in Tamoxifen Resistant Breast Cancer Cell Lines are Mediated by Down Regulation of GSS and XDH and Correlated to Poor Prognosis Adipocyte derived glutathione promotes obesity related breast cancer by regulating the SCARB2 ARF1 mTORC1 complex: Cell Metabolism Involvement of glutathione peroxidases in the occurrence and development of breast cancers Journal of Translational Medicine Springer Nature Link

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134 NoctorG.MhamdiA.ChaouchS.HanY.NeukermansJ.Marquez-GarciaB.et al (2012)

As postulated by Zechmann (2020) and Otulak-Kozie et al

Notably, canonical GPX4 inhibitors, such as RSL3 and ML162, also inhibit thioredoxin reductase 1 (TXNRD1) 121,122

Since GSH is the final product of the homocysteine metabolism in the transsulfuration pathway by transferring sulfur from homocysteine to cysteine, a deficiency in transsulfuration pathway leads to excessive homocysteine production (hyperhomocysteinemia) and reduced GSH synthesis (159, 160)