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The same fate is fulfilled with the upregulation of IRPs [98, 99], the downregulation of FPN1 [100, 101], and the increased production of hepcidin, trapping more iron within cells [102]

and in terms of vascular barrier function, the loss of HS exposes adhesion molecules, promoting the adhesion of leukocytes and platelets, triggering inflammation and thrombosis, and further impairing renal blood supply and glomerular filtration, ultimately leading to a decrease in GFR (100)

Furthermore, bavachin upregulated the expression of the transferrin receptor and DMT1 while downregulating the expression of FTL and FTH

Molecular weight: Glutathione weighs 307.32 g/mol