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In women, progesterone and estrogen levels keep fluctuating throughout life due to menstruation, pregnancy, and menopause which also influence their fat storage and metabolism

doi: 10.1016/j.ecoenv.2022.113630 238 WuH.CuiH.FuC.LiR.QiF.LiuZ.et al

Their extensive animal research was funded by HDRF

Notably, cancer cells can affect the microenvironment by releasing cell signaling molecules to promote tumor angiogenesis and induce immune tolerance, while immune cells in the microenvironment could regulate the growth and development of cancer cells