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Analyzing the metabolic profiles of these patient groups may reveal commonly dysregulated pathways that contribute to these shared symptoms

Despite the substantial evidence and promising hypotheses, further research and clinical investigations are necessary to fully understand the role of polyphenols and establish them as advanced therapeutic targets for age-related neurodegenerative diseases and neuroinflammatory conditions

2.1 Physical and chemical synthesis Physical methods, such as evaporation-condensation, spark discharge, and pyrolysis, offer rapid synthesis without hazardous chemicals but suffer from high energy consumption, low yield, and inconsistent particle distribution (Kruis et al., 2000

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