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These antigens would eventually be recognized by B and T cells, triggering creation of a proinflammatory environment with release of cytokines and activation of fibroblasts along with increased production of collagen.62 TGF- also appears to play an important role.62 The induration may improve spontaneously but, like idiopathic morphea, the radiation-induced form presents therapeutic challenges

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Ratajczak, J

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