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Coagulation can also occur via the intrinsic pathway when blood is exposed to negatively charged surfaces, leading to the activation of FXII by high molecular weight kininogen (HMWK) and prekallikrein [31]

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sublingual/injection routes can bypass this

At physiological concentrations ranging from 0.1 to 10 M, pyocyanin showed amplification of contractions in resting coronary arteries by inducing contractions of small amplitude, strengthening prostaglandin F 2 -induced contractions, and inhibiting vascular relaxations even in the presence of relaxants such as neurokinin A, diethylamine nitric oxide, forskolin, dibuytyryl-cAMP, 8-bromo-cGMP, and P1075

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