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The detrimental effects of ROS on cartilage homeostasis can be effectively alleviated by augmenting cellular antioxidant activity under stress conditions, and several attempts have been made to treat OA by targeting the regulators involved in oxidative stress production in cartilage 84,85,86

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To prevent the formation of AChR clusters in extrasynaptic sites, and to reduce the risk of tetanic contraction caused by an overstimulation of the muscle, several negative regulators control the clustering pathway and the expression of AChRs on the muscle membrane