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Methionine synthase catalyzes the transfer of a methyl group to S-adenosyl-homocysteine, generating S-adenosyl-methionine and hence methionine, while methylmalonyl-CoA mutase catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, which then enters the citric acid cycle (Figure 1) [4,5,6]

Below are symptoms commonly attributed to b12 deficiency: Anemia Fatigue Weakness Constipation Loss of Appetite Weight loss Numbness or Tingling Depression Confusion Memory Impairment Burning Tongue/Mouth Dosages A 2015 paper published by the EFSA Panel on Dietetic Products considered 8 separate studies on Vitamin B12 ranging in dosages of 1.5-3.0 mcg/day

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