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Deficiency of substrate L-Arg and accumulation of ADMA L-Arg is the substrate for eNOS and the main precursor of NO, therefore, the availability of L-Arg is important for the activity of this enzyme, and the substrate insufficiency may lead to eNOS uncoupling (Fig

Poloxamer: A versatile tri-block copolymer for biomedical applications, Acta Biomaterialia 110 (2020) 3767

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Schulz et al., 2007