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Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively

Regarding the cytoarchitecture of SURF1 organoids, they show a disorganized neural progenitor pattern and disrupted neuroepithelial layers that confirmed the dysregulation of NPC function and morphogenesis

Sci Rep 7(1):9433 Wei S, Pei Y, Wang Y, Guan H, Huang Y, Xing T et al (2019) Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2