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12 These hormones are able to bind to the PXR and when they do, the body increases its production of CYP3A4 and the hormones in question will be metabolized more rapidly.13 Therefore, the PXR creates a negative feedback loop which effectively places a thermostat on the hormonal system to maintain consistent levels of certain hormones

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In addition, many EHC monographs have been devoted to evaluating toxicological methodology, e.g., for genetic, neurotoxic, teratogenic and nephrotoxic effects

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