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Looking at identified cellular targets, MOR decreases glutamate input to both GABA and 5-HT neurons (Chen et al., 2016)

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Months 3-6: Approaching the Maintenance Phase What the trials documented: By around month four (week 17), the REDEFINE protocol reached the 2.4 mg maintenance dose, and weight loss continued to accrue beyond that point through the 68-week primary endpoint (Aronne et al., 2025)

doi: 10.1016/j.exphem.2023.08.001 55 JamrusP.PholngamN.KiatpakdeeB.ViwatpinyoK.VadolasJ.NgampramuanS.et al

We cover its side effects in its dedicated section later in the guide