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By lysis of tumor cells, the cytotoxic T lymphocytes (CTLs) contribute to antiviral therapy

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Corticosteroids may be considered in refractory cases

Pro-inflammatory cytokines i.e., TNF- and IL-1 may activate the serotoninergic transporter (SERT) via the stimulation of the p38 MAPK pathway, increasing the concentration of other catecholamines in specific brain regions such as the anterior hypothalamus (Zhu et al