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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig

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The following genomic coordinates (hg38) were used as the qPCR amplicon targets: ARBS1: chr18:63,321,54363,321,592 (50 bp)

Estas haptocorrinas transportan B12 pero no hacen entrega de la vitamina, tiene alta afinidad por anlogos inactivos de B12, aunque se cree que por ello tambin pueden tener un papel en la eliminacin de estos, y otras funciones que estn an en estudio y se desconoce bastante (entre ellas, el transporte de la B12 de almacenamiento)