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A 2023 study found viral RNA and protein in multiple tissue sites, including the gut, lymph nodes, and brain, up to 12 months post-infection in some patients

Nrf2-ARE pathway In vitiligo, inactive Nrf2 signaling is ineffective in protecting HEM from H 2 O 2 -induced OS damage and, therefore, rarely prevents melanocyte apoptosis by mediating its downstream antioxidant gene heme oxygenase-1 (HO-1) (120)