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This angiogenic effect accelerates healing by improving cellular metabolism and waste removal in damaged areas

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In a clinical trial of 71 women with mild to advanced photoaging, a GHK-Cu facial cream applied daily for twelve weeks significantly increased skin density and thickness while reducing fine lines, wrinkles, and laxity

In addition to acting on opioid receptors, opioid peptides have also been shown to interact with toll-like receptors (TLR), particularly TLR4 (Eidson and Murphy 2013