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They prevent the phosphorylation and/or nuclear translocation of Smad2/3 or Smad1/5/8complexes and induce their degradation by recruiting ubiquitin ligases (Gangji et al., 2009

Also, these factors can switch on stromal reprogramming, further remodeling the pre-metastatic niche [51]

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In contrast, more severe toxicity was observed when rat or human liver slices were incubated with AMAP than when mouse liver slices were incubated with the compound, or when rat and human liver slices were incubated with acetaminophen

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