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Oral administration, if viable (which for most peptides, it's not due to gastric degradation), would likely lead to an even shorter effective half-life due to first-pass metabolism

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The LD control group was particularly distinct from the other groups in the unweighted UniFrac and BrayCurtis dissimilarity analyses plots, suggesting that animals exposed to the same diet at an early age in life diet develop similar microbiome profiles that persist even after an acute change in diet