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J Biol Chem 278:1202912038 Li X, Orwar OWE, Revesj C, Sandberg M (1996) -glutamyl peptides and related amino acds in rat hippocampus in vitro: effect of depolarisation and -glutamyl transpeptidase inhibition

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Its extreme local potency, coupled with the systemic risks inherent to IGF-1 (such as potential tumor acceleration and long-term changes in glucose regulation), means its use should be strictly confined to controlled research settings with rigorous safety monitoring

The most often used igf1 lr3 dosage per day in research is 40-80 mcg, gave once daily via under-skin injection