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The brain is in a metabolic crisis in a concussion, potassium ion from inside the cell going extracellular, calcium ions going intracellular, neurotransmitters widely released in a chaotic manner

Loibl, M

Wiley, 2008 4.Gavrilova SI, Kalyn IaB, Kolykhalov IV

Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A charge gradient directs superoxide anion towards the active site since 89% of the exposed surface is negatively charged, whereas the active site and the channel leading to it are positively charged