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Homocysteine, through activation of NMDA receptors, induces Ca +2 , leading to excitotoxicity, astrocyte activation with release inflammatory mediators, and matrix metalloproteinase (MMP) activation with subsequent BBB injury and microvascular inflammation (Kamat et al

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In addition to these roles, the Golgi regulates several cellular processes, including mitosis, DNA damage responses, stress responses, autophagy, apoptosis and inflammation 71,72