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This process supports enhanced fat metabolism, energy levels, and cellular repair, particularly within muscle and fat tissue

CREB: Cyclic AMP Response Element Binding Protein

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Among the key causative agents, anthracyclines, such as doxorubicin (DOX), are particularly notable, as the severe cardiac damage they inducecharacterized by ventricular dilatation, interstitial fibrosis, and progression to HFsignificantly limits their clinical utility [73]

doi: 10.1111/j.1756-185X.2009.01375.x 37