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APOE4 is less stable and more prone to proteolytic degradation, leading to reduced functional persistence inside and outside the cell

162,163 Finally, ATP-binding cassette subfamily G member 2 (ABCG2) is a drug-exporting transporter protein that enhances drug resistance and promotes CSC survival under chemotherapeutic stress

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Activation of the PINK1/Parkin pathway restores mitophagy, reduces pathological protein burden, reverses cognitive decline, and improves synaptic function in experimental AD models