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For consolidation and maintenance therapy, further case studies and multicenter clinical trials are needed to confirm whether ATRA combined with ATO is the optimal approach

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The protein Rel-Mtb modulates the intracellular (p)ppGpp content by regulating its synthesis and hydrolysis via an N-terminal hydrolase and synthetase domain ( Rv2583c ( Rel-Mtb ) that subsequently promotes the production of intracellular (p)ppGpp in Mtb ( Rel-Mtb deletion mutant showed a growth defect in liquid media, and the disrupted growth rate was restored when citrate or phospholipid was used as the sole carbon source in vitro ( in vitro nutrient starvation and BALB/c mouse models ( ppx1 or ppk2 deletion mutant strains showed low glycerol-3-phosphate (G3P) and 1-deoxy-xylulose-5-phosphate expression levels in bacterial cells, suggesting downregulated G3P synthesis pathway ( ppk2 and ppx1 deletion mutant increased susceptibility to plumbagin and meropenem, and clofazimine, respectively ( in vivo

A study ( Epinephelus coioides ), the mechanism involves significant downregulation of immune-related genes following PS-NP exposure, which accelerates viral replication and reduces cellular and tissue resistance to viral infection

A decrease in bone mineral density (BMD) is a characteristic of patients with T1DM