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Multiple oxidation and antioxidant systems can be activated simultaneously and run in parallel to adjust this threshold, which is associated with metabolic reprogramming of the affected cell

Within MSFraggers, precursor mass tolerance was set to +/-20ppm, fragment mass tolerance was set to +/-20ppm, tryptic cleavage specificity was applied, as well as fixed methionine oxidation and fixed N-terminal acetylation

Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S

In general, G6PD mutations are position-specific and may cause severe deficiency if they abrogate functional domains of the protein, such as dimerization and alteration of the substrate binding interface

Exenatide (Byetta), approved in 2005, was based on exendin-4, a naturally occurring peptide from the Gila monster with inherent DPP-4 resistance