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Transcription-translation feedback loops of clock genes directly or indirectly regulating their own transcription underlie many functions of the clock, and drive oscillations of output genes controlling physiology and behavior

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Nevertheless, recent concerns regarding the development of antibodies against PEG in healthy blood donors prompt further exploration of potential implications for the efficacy of PEGylated pharmaceuticals

Consequently, the continuous use of metformin during pregnancy among females with PCOS may serve as a beneficial approach to enhancing the likelihood of full-term pregnancy while mitigating the risks associated with early miscarriage and preterm delivery

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