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Collectively, the roadmap toward clinical translation should include systematic human safety and pharmacokinetic studies, biomarker-driven and phenotype-stratified randomized controlled trials, rigorous exploration of combination regimens, and incorporation of patient-centered outcomes

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Collectively, these OFF-to-ON switching strategies illustrate therapeutic approaches in which GSH acts as a biological trigger for selective activation of cytotoxic agents in the GSH-rich tumor microenvironment

human clinical data is limited