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Doctors can make a lupus diagnosis based on the results of urine and blood tests, such as: Urinalysis: red blood cells and proteinuria (protein in the urine) may be indicative of lupus nephritis Kidney and liver function: these blood tests are used to detect liver or kidney problems Complete blood count: abnormal levels of hemoglobin, white blood cells, or platelets may occur in lupus Erythrocyte sedimentation rate (ESR): This test is not specific for lupus