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The Role of Glutathione in Skin Health When it comes to skin health, glutathione is often praised for its ability to: Brighten the skin: Glutathione inhibits melanin production, making it a popular choice for those seeking a more even skin tone and reduced pigmentation

Further studies suggested that the mechanism might involve the suppression of the TLR4/MyD88/NF-B signaling pathway by AS-IV, which downregulates the expression of downstream inflammatory cytokines such as TNF-, IL-6, and IL-8, thereby alleviating the inflammatory response induced by liver steatosis (Liu et al., 2020)

For further biological evaluation, co-culture systems and reconstructed skin models should be adopted to screen for the ability of the novel compounds to interfere with the melanogenesis process, especially following stimuli including UV irradiation, exposure to a-MSH or proinflammatory cytokines

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